Pregnancy, but not dietary octanoic acid supplementation, stimulates the ghrelin-pituitary growth hormone axis in mice
نویسندگان
چکیده
منابع مشابه
Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice.
OBJECTIVE Ghrelin is produced by the stomach, hypothalamus and pituitary. It circulates as acylated ghrelin (AG, which stimulates growth hormone (GH) secretion) and unacylated ghrelin (UAG). Acylation is mediated by the enzyme ghrelin O-acyltransferase (GOAT). In mice, pregnancy is associated with a marked increase in circulating pituitary GH. We investigated the role of AG and UAG in the surge...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2020
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-20-0072